Roberta Sherwood began in a vaudeville and nightclub act but rose to fame at the age of 43 because of Red Buttons and Walter Winchell.

Cheryl Holdridge, best known as an original cast member of The Mickey Mouse Club, guest stars in Season 5 of The Donna Reed Show.

Award-winning Jack Albertson, a veteran of vaudeville, burlesque, and Broadway, made three guest appearances on The Donna Reed Show.

Paul Reed, known for his trademark "slow burn", guests in two episodes of The Donna Reed Show - "Trees" and "My Son the Councilman."

Barbara Avedon began her screenwriting career as an episodic writer for The Donna Reed Show, where she wrote 15 scripts.

Singer James Darren made two appearances on The Donna Reed Show. Watch him sing to Mary (Shelly Fabares) on their date.

Bobby Burgess, an original Mouseketeer and later a regular on The Lawrence Welk Show, also made an appearance on The Donna Reed Show.

When The Donna Reed Show premiered, Campbell's Soup was the sponsor. By the fourth show, everyone was prepared for the show to be canceled.

Richard Deacon had recurring roles in television shows such as The Dick Van Dyke Show, Leave It To Beaver, and The Donna Reed Show.

Character actor Doodles Weaver appears in four episodes of The Donna Reed Show in seasons 3, 4, and 5.

Miyoshi Umeki, known for her role in the television series The Courtship of Eddie’s Father, appears in two episode of The Donna Reed Show.

Professional baseball center fielder Willie Mays appears in three episodes of The Donna Reed Show (S6, Ep31), (S7, Ep3) and (S8, Ep 20).

Lesley Gore recorded the pop hit "It's My Party" (1963). She appears in the last episode of The Donna Reed Show singing, "It's My Party."

Cloris Leachman, actress and comedienne from Des Moines, Iowa, guest-stars on The Donna Reed Show in "Mouse at Play" (S4, Ep 4).

Florence MacMichael guests in two episodes of The Donna Reed Show - "The Fatal Leap" ( S2, Ep 26) and "The Poodle Parlor” (S3, Ep 26).

Lori Martin, known for her role on National Velvet, appears on The Donna Reed Show in “All Women Are Dangerous” (Season 5 Episode 32).

Between 1959 and 1961, Tommy Ivo appeared in five episodes of The Donna Reed Show as Mary's boyfriend, Herbie Bailey.

Hans Conried (Uncle Tonoose on Make Room for Daddy) guests on The Donna Reed Show in “It’s the Principle of the Thing” ( S1, Ep18).

Harry Morgan (M*A*S*H) has more than 100 films to his credit. He appears with Donna Reed in Gentle Annie (1944) and Backlash (1956).

Roberta Shore began her career at age ten, singing country-western songs at supermarket openings with Tex Williams.