Kathleen Freeman plays the riotous neighbor, Mrs. Wilgus, in four episodes of The Donna Reed Show. She later taught at the Donna Festival.

Stuart Erwin guest stars as Mr. Burton on The Donna Reed Show in "The Playmate" (Season 6, Episode 1).

Allan Hunt, best remembered as Crewman Stuart Riley on Voyage to the Bottom of the Sea, appeared on four episodes of The Donna Reed Show.

Eddie Foy III was a casting director with strong connections to Donna Reed and her hometown of Denison, Iowa.

Gigi Perreau achieved success as a child actress, appearing with Donna Reed in "Green Dolphin Street" (1947) and on The Donna Reed Show.

Ida Lupino appeared in 59 films and directed 8 others. She also directed over 100 episodes of tv productions including The Donna Reed Show.

John Fiedlier made a guest appearance on The Donna Reed Show. He's known for roles in The Bob Newhart Show, and The Odd Couple (1968).

John Banner, best known as Sergeant Schultz on Hogan's Heroes, guest-starred on The Donna Reed Show in "Moon Shot" (Season 6, Episode 14).

Donna Reed's career spanned more than 40 years, with performances in more than 40 films and 275 episodes of The Donna Reed Show.

Estelle Winwood appears in the role of Miss Lovelace in Miss Lovelace Comes To Tea (Season 1, Episode 34) of The Donna Reed Show.

DeForest Kelley appears as Mr. Williams in Uncle Jeff Needs You (Season 8, Episode 14) of The Donna Reed Show.

Arte Johnson appears as Crandall in "Is There a Small Hotel" (Season 8, Episode 23) of The Donna Reed Show.

Shelley Fabares is best known for her television roles as Mary Stone on the sitcom The Donna Reed Show (1958–1963).

Eddie Foy III served as the casting director for The Donna Reed Show. Watch an interview as he talks about Donna Reed.

Campbell's Soups helped The Donna Reed Show. Although the series ratings were especially tame in the beginning, its sponsor didn't bail.

Jesse White appears in The Donna Reed Show episode “April Fool” as the manager of a teen singing idol played by James Darren.

Dabney Coleman guest-starred in The Donna Reed Show episode, “Rally Round the Girls, Boys” (Season 8, Episode 12).

Rhys Williams appears on The Donna Reed Show in The Busy Body (Season 1, Episode 13), playing the part of Donna’s uncle.

Tony Martin guest-stars on The Donna Reed Show in "Tony Martin Visits" (Season 3, Episode 24) when they met in traffic court.

Charles Herbert made four guest appearances on The Donna Reed Show during Season 1 and Season 2.